Gender-based violence (GBV) is a major problem throughout the world. It includes sexual, physical, emotional, and financial abuse; structural discrimination (institutional structures that result in disparities or stigmatization in services); state-sponsored violence (i.e., persecution of sex workers, men who have sex with men, women living with HIV); and trafficking of women and girls. GBV primarily affects women and girls, but men, boys, and gender minority communities are also impacted. Reducing GBV is one of the five gender strategies promoted through the U.S. President’s Emergency Plan for AIDS Relief. The purpose of this technical brief is to assist HIV program planners and implementers in designing, planning, and implementing activities that integrate GBV and HIV prevention, treatment and care, and support programs.